Astragalus polysaccharides combined with ibuprofen exhibit a therapeutic effect on septic rats via an anti-inflammatory cholinergic pathway
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Cholinergic Anti-Inflammatory Pathway Dysfunction of the Cholinergic Anti-Inflammatory Pathway Mediates Organ Damage in Hypertension
Inflammatory responses are associated with the genesis and progression of end-organ damage (EOD) in hypertension. A role for the 7 nicotinic acetylcholine receptor ( 7nAChR) in inflammation has recently been identified. We tested the hypothesis that 7nAChR dysfunction contributes to hypertensive EOD. In both spontaneously hypertensive rats (SHRs) and rats with abdominal aorta coarctation–induce...
متن کاملControlling inflammation: the cholinergic anti-inflammatory pathway.
Innate immune responses and inflammation are regulated in part by neural mechanisms. In the present paper, we summarize experimental evidence that reveals that innate immunity and inflammation are controlled by the vagus nerve, previously known as a regulator of other vital physiological functions. Activation of vagus nerve cholinergic signalling inhibits TNF (tumour necrosis factor) and other ...
متن کاملCholinergic Anti-Inflammatory Pathway and the Liver
The hepatic vagus branches innervate the liver and serve an important role in liver-brain connection. It appears that brain modulates inflammatory responses by activation of vagal efferent fibers. This activation and subsequent acetylcholine releases from vagus nerve terminals leads to inhibition of inflammatory cytokines through α7 nicotinic acetylcholine receptors (α7nAChRs) which located on ...
متن کاملMicroRNAs in the Cholinergic Anti-Inflammatory Pathway: Prospective Therapeutic Targets for Inflammatory Diseases
The host inflammatory response can be self-limited or progress to immunological and inflammatory diseases. It has been well known that humoral anti-inflammatory mechanisms, including IL-10, TGF-β1, glucocorticoids and other cytokine inhibitors, can protect tissue against cytokine-induced damage in humans. Recent advances have identified a brain to immune system mechanisms, termed cholinergic an...
متن کاملThe cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis.
BACKGROUND The nervous system, through the vagus nerve, can down-regulate inflammation in vivo by decreasing the release of tumor necrosis factor- alpha by endotoxin-stimulated macrophages. This anti-inflammatory effect is mediated by an interaction between acetylcholine, the principal neurotransmitter of the vagus nerve, and cholinergic nicotinic acetylcholine receptors on macrophages. METHO...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2017
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2017.4865